Can we predict unresponsiveness to methotrexate in rheumatoid arthritis? A pharmacogenetic study.
Meltem Alkan MelikogluEda BalkanPublished in: Inflammopharmacology (2022)
We determined heterozygosity in C3435T SNP of ABCB1 gene (multidrug resistant 1 gene) in almost all patients with RA who were non-responders to MTX. This result may contribute to predict unresponsiveness to MTX in RA. Individualized treatment strategies based on the pharmacogenetic characteristics of MTX may lead to optimization of the treatment.
Keyphrases
- rheumatoid arthritis
- genome wide
- multidrug resistant
- disease activity
- copy number
- ankylosing spondylitis
- interstitial lung disease
- genome wide identification
- dna methylation
- high dose
- systemic lupus erythematosus
- gram negative
- gene expression
- acinetobacter baumannii
- escherichia coli
- systemic sclerosis
- low dose
- klebsiella pneumoniae
- idiopathic pulmonary fibrosis
- high density