Erastin induces ferroptosis in cervical cancer cells via Nrf2/HO-1 signaling pathway.

Xiaoning Wei Qiaoqiao Huang Jinbing Huang Li Yu Junying Chen

Published in: International journal of immunopathology and pharmacology (2023)

Our research demonstrates that erastin induces ferroptosis and the accumulation of ROS in cervical cancer cells by activating the Nrf2/HO-1 pathway, significantly reducing cell proliferation and motility. These findings propose a potential molecular mechanism of erastin-mediated cervical cancer development.

Keyphrases

pi k akt
signaling pathway
cell death
cell proliferation
oxidative stress
epithelial mesenchymal transition
induced apoptosis
dna damage
biofilm formation
human health