Long-term effect of indomethacin on a rat model of neonatal hypoxia ischemic encephalopathy through behavioral tests.

Tugay Tepe Mehmet Satar Mustafa Ozdemir Hacer Yapıcıoğlu Yıldızdaş Ferda OzlüSeyda ErdoganTugba ToyranKübra Akıllıoğlu Seda Köse Çağrı Avci

Published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2023)

In this study, we have shown for the first time that indomethacin treatment can reduce levels of anxiety-like behavior and enhance levels of exploratory behavior in a neonatal rat model with HIE. It is necessary to determine whether nonsteroidal anti-inflammatory agents, such as indomethacin, should be used for adjuvant therapy in newborns with HIE.

Keyphrases

anti inflammatory
pregnant women
early onset
endothelial cells
ischemia reperfusion injury
low birth weight
physical activity
oxidative stress
depressive symptoms