Long-term effect of indomethacin on a rat model of neonatal hypoxia ischemic encephalopathy through behavioral tests.
Tugay TepeMehmet SatarMustafa OzdemirHacer Yapıcıoğlu YıldızdaşFerda OzlüSeyda ErdoganTugba ToyranKübra AkıllıoğluSeda KöseCagri AvciPublished in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2023)
In this study, we have shown for the first time that indomethacin treatment can reduce levels of anxiety-like behavior and enhance levels of exploratory behavior in a neonatal rat model with HIE. It is necessary to determine whether nonsteroidal anti-inflammatory agents, such as indomethacin, should be used for adjuvant therapy in newborns with HIE.