Novel therapeutic modalities target cell signaling of Renin-Angiotensin system/NF-κB-induced cell cycle arrest and apoptosis in urethane-induced lung cancer in mice: An in vivo study.
Marwa M KhalafAmira M Abo-YoussefMarina N MalakMohamed A HamzawyPublished in: Journal of biochemical and molecular toxicology (2022)
RAS/NF-B cell signaling is a potential therapeutic target for preventing and treating lung adenocarcinoma, evidenced by the fundamental cytotoxic mechanism and attenuation of metastasis and angiogenesis induced by the treatment of NSCLC mice with aliskiren.
Keyphrases
- cell cycle arrest
- pi k akt
- cell death
- signaling pathway
- oxidative stress
- high glucose
- diabetic rats
- small cell lung cancer
- lps induced
- endothelial cells
- high fat diet induced
- wild type
- single cell
- cell proliferation
- drug induced
- stem cells
- cell therapy
- risk assessment
- vascular endothelial growth factor
- type diabetes
- mesenchymal stem cells
- skeletal muscle
- climate change
- toll like receptor
- combination therapy