Cardiac MRI Myocardial Functional and Tissue Characterization Detects Early Cardiac Dysfunction in a Mouse Model of Chemotherapy-Induced Cardiotoxicity.
Nivedita K NareshSol MisenerZhouli ZhangCynthia YangAlexander RuhNicola BertolinoFrederick H EpsteinJeremy C CollinsMichael MarklDaniele ProcissiJames C CarrBradley D AllenPublished in: NMR in biomedicine (2020)
In a mouse model of chemotherapy-induced cardiotoxicity using doxorubicin and trastuzumab, advanced CMR shows promise in identifying treatment-related decrease in myocardial velocity and native T1 prior to the onset of cardiomyocyte apoptosis and reduction of EF.
Keyphrases
- chemotherapy induced
- mouse model
- left ventricular
- oxidative stress
- magnetic resonance imaging
- endoplasmic reticulum stress
- heart failure
- cell death
- drug delivery
- contrast enhanced
- epidermal growth factor receptor
- cell cycle arrest
- angiotensin ii
- big data
- magnetic resonance
- computed tomography
- combination therapy
- endothelial cells
- machine learning
- high glucose
- signaling pathway
- tyrosine kinase