Global identification of hnRNP A1 binding sites for SSO-based splicing modulation.

Gitte H BruunThomas K DoktorJonas Borch-JensenAkio MasudaAdrian R KrainerKinji OhnoBrage Storstein Andresen

Published in: BMC biology (2016)

The hnRNP A1 binding map can be used to identify potential targets for SSO-based therapy. Moreover, together with the hnRNP A1 consensus binding motif, the binding map may be used to predict whether disease-associated mutations and SNPs affect hnRNP A1 binding and eventually mRNA splicing.

Keyphrases

binding protein
dna binding
risk assessment
transcription factor
bone marrow
mesenchymal stem cells
clinical practice
smoking cessation