Benzoylaconitine Alleviates Progression of Psoriasis via Suppressing STAT3 Phosphorylation in Keratinocytes.
Yuanbo LiDandan GuoQianqian WangAifang LiSugai YinShuxuan LiYalan LiBaiyan WangTao GuoShuying FengPublished in: Molecules (Basel, Switzerland) (2023)
Psoriasis is a chronic and multifactorial skin disease which is caused by inflammatory infiltrates, keratinocyte hyperproliferation, and accumulation of immune cells. As part of the Aconitum species, Benzoylaconitine (BAC) shows potential antiviral, anti-tumor, and anti-inflammatory effects. In this study, we investigated the effects and mechanisms of BAC on tumor necrosis factor-alpha (TNF-α)/LPS-induced HaCaT keratinocytes in a imiquimod(IMQ)-induced mice model. The results showed that BAC could relieve the symptoms of psoriasis by inhibiting cell proliferation, the release of inflammatory factors, and the accumulation of Th17 cells, while no obvious effect on cell viability and safety was observed both in vitro and in vivo. Additionally, BAC can markedly inhibit the protein and mRNA levels of inflammatory cytokines in TNF-α/LPS-induced HaCaT keratinocytes by inhibiting the phosphorylation of STAT3. In brief, our data indicated that BAC could alleviate the progression of psoriasis and may be a potential therapeutic agent for treating psoriasis in clinical practice.
Keyphrases
- lps induced
- inflammatory response
- cell proliferation
- rheumatoid arthritis
- signaling pathway
- clinical practice
- wound healing
- atopic dermatitis
- oxidative stress
- type diabetes
- drug induced
- high glucose
- endothelial cells
- pi k akt
- cell cycle arrest
- high fat diet induced
- soft tissue
- deep learning
- amino acid
- high resolution
- machine learning
- protein protein
- human health
- mass spectrometry
- sleep quality
- climate change