Diagnosis and Outcomes of Late-Onset Wilson's Disease: A National Registry-Based Study.
Christelle NillesMickael Alexandre ObadiaRodolphe SobeskyJérôme DumortierOlivier GuillaudChloé LaurencinCaroline MoreauClaire VanlemmensFabienne Ory-MagneVictor de LedinghenEdouard Bardou-JacquetFrederique FluchèreCorinne ColletNouzha Oussedik-DjebraniFrance WoimantAurélia PoujoisPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
In the FWDR, late-onset forms of WD affect 8% of patients, mostly with neurological presentations. Thirty percent of the neurological forms were atypical (isolated long-lasting symptoms, inconspicuous brain MRI, no KFR). With personalized treatment, prognosis was good. This study emphasized that WD should be suspected at any age and even in cases of atypical presentation. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
- late onset
- early onset
- end stage renal disease
- ejection fraction
- newly diagnosed
- magnetic resonance imaging
- chronic kidney disease
- computed tomography
- peritoneal dialysis
- pulmonary embolism
- quality improvement
- depressive symptoms
- multiple sclerosis
- contrast enhanced
- magnetic resonance
- case report
- replacement therapy