Pd-catalyzed allylative dearomatisation using Grignard reagents.
Marta Castiñeira ReisSyuzanna R HarutyunyanPublished in: Chemical communications (Cambridge, England) (2021)
Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.