The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.

Mahmoud El-BendaryM NeamatallahHatem Elalfy Tarek BesheerA ElkholiM El-DiastyM ElsareefM ZahranB El-AaragA GomaaD ElhammadyM El-SetouhyA HegazyG Esmat

Published in: British journal of biomedical science (2018)

The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.

Keyphrases

toll like receptor
inflammatory response
nuclear factor
immune response
hepatitis c virus
human immunodeficiency virus
gene expression
transcription factor
bioinformatics analysis
antiretroviral therapy