Incidence of tolerance in children undergoing repeated administration of propofol for proton radiation therapy: a retrospective study.
RyungA KangByung Seop ShinYoung Hee ShinNam-Su GilYe Na OhJi Seon JeongPublished in: BMC anesthesiology (2018)
Repeated prolonged deep sedation for PRT elicited multiple times over several weeks in young children using propofol did not develop tolerance in 74% of patients. Although the incidence of 26% tolerance to propofol may still be present, the increase in propofol dose was minimal. Therefore, the use of repeated propofol for children was safe.