Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size.
Laís Akemi YamadaIsabela Ramos MarianoVanessa Lara Rissi SabinoRenan Soares RabassiCamila BatagliniSilvia Carla Santana Ferreira AzevedoNayra Thais Delatorre BranquinhoMirian Ayumi KurautiRosângela Fernandes GarciaMaria Montserrat Diaz PedrosaPublished in: Nutrition & metabolism (2019)
As glucose output was not affected by litter size, liver glucose metabolism in the adult rat, in contrast to other metabolic processes, is not a programmed effect of the nutritional condition during lactation. In addition, the increased expression of PKA points to a higher sensitivity of the animals under caloric restriction to glycogenolytic hormones, a relevant condition for glucose homeostasis during fasting.