Anemoside B4 protects against Klebsiella pneumoniae- and influenza virus FM1-induced pneumonia via the TLR4/Myd88 signaling pathway in mice.
Jia HeRenyikun YuanXiaolan CuiYushun CuiShan HanQin-Qin WangYangling ChenLiting HuangShilin YangQiongming XuYonghui ZhaoHongwei GaoPublished in: Chinese medicine (2020)
Our findings demonstrated that anemoside B4 attenuates pneumonia via the TLR4/Myd88 signaling pathway, suggesting that anemoside B4 is a promising therapeutic candidate for bacterial-infected or viral-infected pneumonia.
Keyphrases
- toll like receptor
- signaling pathway
- klebsiella pneumoniae
- inflammatory response
- pi k akt
- multidrug resistant
- immune response
- escherichia coli
- epithelial mesenchymal transition
- nuclear factor
- respiratory failure
- community acquired pneumonia
- sars cov
- induced apoptosis
- type diabetes
- metabolic syndrome
- insulin resistance