Optimal management of lenvatinib therapy for patients with unresectable hepatocellular carcinoma by balancing the therapeutic effect with the relative dose intensity.
Takayuki TokunagaMasakuni TateyamaKentaro TanakaSatoshi NaraharaHiroki InadaSotaro KuranoSanae HayashiYoko YoshimaruKatsuya NagaokaTakehisa WatanabeHiroko SetoyamaMotohiko TanakaYasuhito TanakaPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2021)
To achieve OR and SD for a favorable outcome of first- or later-line LEN, high and moderate early-phase RDI are required, respectively. The degree of RDI during LEN and tolerance need compatible by dose modifications.