Straightforward synthesis of bench-stable heteroatom-centered difluoromethylated entities via controlled nucleophilic transfer from activated TMSCHF 2 .

The commercially available and experimentally convenient (bp 65 °C) difluoromethyltrimethylsilane (TMSCHF 2 ) is proposed as a valuable difluoromethylating transfer reagent for delivering the CHF 2 moiety to various heteroatom-based electrophiles. Upon activation with an alkoxide, a conceptually intuitive nucleophilic displacement directly furnishes in high yields the bench-stable analogues.