Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy.
Liuzhou MaoPanqin MaXi LuoHongwei ChengZhanxiang WangEnyi YeXian Jun LohYun-Long WuZibiao LiPublished in: ACS nano (2023)
The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment of cancer and a variety of infectious diseases due to their superior biocompatibility, lower toxicity and reduced immunogenicity. Particularly, stimuli-responsive polymeric nanocarriers show great promise for delivering antigens and adjuvants to targeted immune cells, preventing antigen degradation and clearance, and increasing the uptake of specific antigen-presenting cells, thereby sustaining adaptive immune responses and improving immunotherapy for certain diseases. In this review, the most recent advances in the utilization of stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications are presented. These sophisticated polymeric nanovaccines with diverse functions, aimed at therapeutic administration for disease prevention and immunotherapy, are further classified into several active domains, including pH, temperature, redox, light and ultrasound-sensitive intelligent nanodelivery systems. Finally, the potential strategies for the future design of multifunctional next-generation polymeric nanovaccines by integrating materials science with biological interface are proposed.
Keyphrases
- cancer therapy
- drug delivery
- infectious diseases
- drug release
- immune response
- induced apoptosis
- oxidative stress
- magnetic resonance imaging
- dendritic cells
- risk assessment
- public health
- machine learning
- cell proliferation
- current status
- toll like receptor
- human health
- case report
- combination therapy
- childhood cancer
- deep learning