Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.

Mark A GregoryTravis NemkovHae J ParkVadym ZaberezhnyySarah GehrkeBiniam AdaneCraig T JordanKirk C HansenAngelo D'AlessandroJames DeGregori

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Targeting glutamine metabolism in combination with drugs that perturb mitochondrial redox state represents an effective and potentially widely applicable therapeutic strategy for treating multiple types of leukemia.

Keyphrases

acute myeloid leukemia
bone marrow
cancer therapy
oxidative stress
electron transfer
cell therapy
replacement therapy