Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors.

Kayoko HosakaChenchen WangShiyue ZhangXue LvTakahiro SekiYin ZhangXu JingJieyu WuQiqiao DuXingkang HeYulong FanXuan LiMakoto KondoMasahito YoshiharaHong QianLihong ShiPing ZhuYuanfu XuYunlong YangTao ChengYihai Cao

Published in: Cancer communications (London, England) (2023)

Our data provide a new concept of hematopoiesis within tumor tissues and novel mechanistic insights into perivascular localized cell-derived erythroid cells within TME. Targeting tumor hematopoiesis is a novel therapeutic concept for treating various cancers that may have profound impacts on cancer therapy.

Keyphrases

cancer therapy
induced apoptosis
cell cycle arrest
drug delivery
gene expression
endoplasmic reticulum stress
oxidative stress
intellectual disability
signaling pathway
pi k akt
deep learning
vascular smooth muscle cells
data analysis