Oncolytic Activity of Wild-type Newcastle Disease Virus HK84 Against Hepatocellular Carcinoma Associated with Activation of Type I Interferon Signaling.
Liming ChenYongdong NiuJiating SunHong LinGuoxi LiangMin XiaoDongmei ShiJia WangHuachen ZhuYi GuanPublished in: Journal of clinical and translational hepatology (2021)
Intratumor infection with NDV/HK84 strains compared with vehicle controls or positive controls indicated that NDV/HK84 strain specifically inhibited HCC without affecting healthy mice. High-throughput RNA sequencing showed that the oncolytic activity of NDV/HK84 was dependent on the activation of type I interferon signaling.