MUS81 cleaves TOP1-derived lesions and other DNA-protein cross-links.

Victoria MariniFedor NikulenkovPounami SamadderSissel JuulBirgitta R KnudsenLumír Krejčí

Published in: BMC biology (2023)

Our data indicate that MUS81 and TDP1 play independent roles in the repair of CPT-induced lesions, thus representing new therapeutic targets for cancer cell sensitisation in combination with TOP1 inhibitors.

Keyphrases

high glucose
diabetic rats
circulating tumor
electronic health record
single molecule
cell free
big data
amyotrophic lateral sclerosis
drug induced
amino acid
machine learning
binding protein
protein protein
endothelial cells
oxidative stress
nucleic acid