Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor.
Tingting GeAmber-Lee PhungGaurang JhalaPrerak TrivediNicola PrincipeDavid J De GeorgeEvan G PappasSara LitwakLaura Sanz-VillanuevaTara CatterallStacey FynchLouis BoonThomas W H KayJonathan CheeBalasubramanian KrishnamurthyHelen E ThomasPublished in: Clinical & translational immunology (2022)
A JAK1/JAK2 inhibitor can prevent and reverse anti-PD-L1-induced diabetes by blocking IFNγ and γc cytokine activities. Our study provides preclinical validation of JAK1/JAK2 inhibitor use in checkpoint inhibitor-induced diabetes.