Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus.
Safir Ullah KhanSaba JannatHadia ShaukatShiza Unabnull TanzeelaMaleeha AkramMuhammad Nasir Khan KhattakMonica Vizcara SotoMuhammad Fiaz KhanAmir AliSyed Shakeel Raza RizviPublished in: Clinical medicine insights. Endocrinology and diabetes (2023)
The patients had significantly elevated cortisol and lower testosterone readings, according to data from hormonal analyses. The bioinformatics approach reveals that SHBG was intracellularly suppressed by 2 defined stress system genes: FKB5 and CYP17. TCF4/TCF8, ATRX, and AR in skeletal muscle were inversely related to stress system genes. Furthermore, all testosterone regulated genes were positively linked with SHBG in the current study. A strong relationship between GNAS and PKA with CYP17 and FKBP5 reveals that the Gαs-cAMP/PKA signaling pathway may be one of the regulatory pathways through which the suppression of testosterone system genes happens. In conclusion, this study demonstrated that beyond stress, the key stress system genes might affect cortisol levels, which in turn affect testosterone figures via the Gαs-cAMP/PKA signaling pathway.
Keyphrases
- stress induced
- replacement therapy
- genome wide
- signaling pathway
- skeletal muscle
- bioinformatics analysis
- pi k akt
- end stage renal disease
- epithelial mesenchymal transition
- transcription factor
- type diabetes
- newly diagnosed
- dna methylation
- genome wide analysis
- binding protein
- adipose tissue
- smoking cessation
- big data
- protein kinase
- patient reported outcomes
- cell proliferation
- quantum dots