TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.

Bin HanZijie PeiLei ShiQian WangChen LiBoyuan ZhangXuan SuNing ZhangLixiao ZhouBo ZhaoYujie NiuRong Zhang

Published in: International journal of nanomedicine (2020)

This work demonstrated that Ti could deposit in lung and enter extra-pulmonary organs of rats and cause oxidative stress, then trigger DNA damage through activating the PI3K-AKT-FOXO3a pathway and then promoting GADD45α, ChK2, and XRCC1 to process the DNA repair.

Keyphrases

dna damage
dna repair
signaling pathway
oxidative stress
pi k akt
dna damage response
pulmonary hypertension
induced apoptosis
transcription factor
epithelial mesenchymal transition
cell death
ischemia reperfusion injury
cell proliferation
quantum dots
walled carbon nanotubes
heat stress