Factors associated with pathological up-staging in MRI cT3a prostate cancer - a retrospective study from a high-volume centre.

Jonathan FergusonDanny Darlington CarbinWissam Abou ChedidSantiago UribeJulian PeacockDimitrios PapadopoulosConstantinos AdamouTorath AmeenUmberto CarbanaraJoseph GabrielVenkata Ramana Murthy KusumaJames HicksDimitrios MoschonasKrishna PatilMatthew Perry

Published in: World journal of urology (2024)

The study has identified PSA level, ISUP, PI-RADS score, tumour volume and percentage coverage are key predictive factors in cT3a upstaging. This study uniquely shows tumour coverage percentage as a predictor of cT3a upstaging on mpMRI. ISUP is the strongest predictor, followed by PI-RADS score and tumour coverage of gland. Multi-institutional studies are needed to confirm our findings.

Keyphrases

prostate cancer
contrast enhanced
computed tomography
image quality
dual energy
magnetic resonance imaging
radical prostatectomy
affordable care act
positron emission tomography
lymph node
healthcare
case control