Synergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of β-catenin.

Reddy Sailaja MundrePavani KokaPrakash DhanarajNitin KhatriSanjana VigYamini ChandramohanAnuradha Dhanasekaran

Published in: PloS one (2017)

Combined treatment of Aza along with AA implicit in inducing cardiomyogenic potential of CDCs and is associated with down regulating Wnt signaling pathway. Altogether, CDCs represent a valuable tool for the treatment of cardiovascular disorders.

Keyphrases

signaling pathway
induced apoptosis
cell proliferation
epithelial mesenchymal transition
stem cells
pi k akt
cell cycle arrest
cancer therapy
climate change
human health