Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.
Faith I UwadiaeChloe J PyleSimone A WalkerClare M LloydJames A HarkerPublished in: Allergy (2018)
TFH are crucial in the regulation of AAD and the ICOS/ICOS-L pathway could represent a novel therapeutic target in allergic asthma.