Proteomic Networks and Related Genetic Variants Associated with Smoking and Chronic Obstructive Pulmonary Disease.
Iain R KonigsbergThao VuWeixuan LiuElizabeth M LitkowskiKatherine A PratteLuciana B VargasNiles GilmoreMohamed Abdel-HafizAni W ManichaikulMichael H ChoCraig P HershDawn L DeMeoFarnoush Banaei-KashaniRussell P BowlerLeslie A LangeKaterina J KechrisPublished in: medRxiv : the preprint server for health sciences (2024)
In this work, we apply state-of-the-art molecular network generation and summarization approaches to proteomic data from COPDGene participants to uncover protein networks associated with COPD phenotypes. We further identify genetic associations with networks. This work discovers protein networks containing known and novel proteins and protein interactions associated with clinically relevant COPD phenotypes across race groups and cohorts.