The impact of CYP3A4 and CYP3A5 genetic variations on tacrolimus treatment of living-donor Egyptian kidney transplanted patients.

Hanaa WanasMai Hamed KamelEmad Adel WilliamTarek FayadMohamed Essmat AbdelfattahHossein Mostafa ElbadawyEmily Samir Mikhael

Published in: Journal of clinical laboratory analysis (2023)

This is the first study on Egyptian population to investigate the impact of CYP3A4*22 and CYP3A5*3 SNPs individually and in combination on the TAC concentration. This study and future multicenter studies can contribute to the individualization of TAC dosing in Egyptian patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
genome wide
copy number