Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12.
Yu ToyodaYusuke KawamuraAkiyoshi NakayamaHirofumi NakaokaToshihide HigashinoSeiko ShimizuHiroshi OoyamaKeito MorimotoNaohiro UchidaRyuichiro ShigesawaKenji TakeuchiIturo InoueKimiyoshi IchidaHiroshi SuzukiNariyoshi ShinomiyaTappei TakadaHirotaka MatsuoPublished in: Rheumatology (Oxford, England) (2021)
Our findings provide a better understanding of gout/hyperuricaemia and its aetiology that is highly relevant to personalized health care. The substantial anti-gout effect of common and rare variants of URAT1 identified in the present study support the genetic concept of a 'Common Disease, Multiple Common and Rare Variant' model.