Chitinase 3-like 1 drives allergic skin inflammation via Th2 immunity and M2 macrophage activation.
Eun Ji KwakJung Yeon HongMi Na KimSoo Yeon KimSeo Hyeong KimChang Ook ParkKyung Won KimChun Geun LeeJack A EliasHye Mi JeeMyung Hyun SohnPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
These findings demonstrate that CHI3L1 mediates the development of AD induced by OVA, affecting Th2 inflammation, M2 macrophage activation and skin barrier function.