Control of DNA integrity in skeletal muscle under physiological and pathological conditions.
Yara Bou SaadaVlada ZakharovaBoris ChernyakCarla DibGilles CarnacSvetlana DokudovskayaYegor S VassetzkyPublished in: Cellular and molecular life sciences : CMLS (2017)
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
Keyphrases
- dna damage
- skeletal muscle
- dna repair
- oxidative stress
- insulin resistance
- reactive oxygen species
- healthcare
- public health
- mental health
- single molecule
- metabolic syndrome
- machine learning
- circulating tumor
- adipose tissue
- risk assessment
- climate change
- health information
- blood brain barrier
- brain injury
- high intensity