A Bayesian adaptive design for clinical trials of rare efficacy outcomes with multiple definitions.
Shirin GolchiJames J WillardEleanor PullenayegumDiego G BassaniLisa G PellKristian ThorlundDaniel E RothPublished in: Clinical trials (London, England) (2022)
Bayesian adaptive designs offer the potential for maximizing the information learned from the data collected through clinical trials. The proposed design enables monitoring and utilizing multiple composite outcomes based on rare events to optimize the trial design operating characteristics.