The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration.
Nader RahimiRachel X Y HoKevin Brown ChandlerKyle Oliver Corcino De La CenaRazie AmraeiAshley J MitchelNels EngblomCatherine E CostelloPublished in: Journal of biomedical science (2021)
TMIGD1 binds to moesin and ezrin, and regulates their cellular localization. Moesin plays critical roles in TMIGD1-dependent acetylation of α-tubulin, mitotic spindle organization and cell migration. Our findings offer a molecular framework for understanding the complex functional interplay between TMIGD1 and the ERM family proteins in the regulation of cell adhesion and mitotic spindle assembly, and have wide-ranging implications in physiological and pathological processes such as cancer progression.