Guideline-directed medical therapy is similarly effective in heart failure with mildly reduced ejection fraction.
Sam StrawCharlotte A ColeMelanie McGinlayMichael DrozdThomas A SlaterJudith E LowryMaria F PatonEylem LeveltRichard M CubbonMark T KearneyKlaus K WitteJohn GierulaPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2022)
Pharmacological therapies were associated with lower mortality risk in HFmrEF, supporting guideline recommendations which extend the indications of these agents to all patients with LVEF < 50%. HFmrEF more closely resembles HFrEF in terms of clinical characteristics and outcomes. Pharmacological therapies are associated with lower mortality risk in HFmrEF and HFrEF, but not in HFpEF.