Chiral Self-Sorting in Pd 6 L 12 Metal-Organic Cages.

Chiral self-sorting during the formation of cage-like molecules continues to fascinate and advance our understanding of the phenomenon in general. Herein, we report the chiral self-sorting in the Pd 6 L 12 -type metal-organic cages. When a racemic mixture of axially chiral bis-pyridyl ligands undergo coordination-driven self-assembly with Pd(II) ions to form Pd 6 L 12 -type cages, the system has the option of chiral self-sorting to afford any of at least 70 pairs of (one homochiral and 69 heterochiral) enantiomers and 5 meso isomers or a statistical mixture of everything. However, the system resulted in diastereoselective self-assembly through a high-fidelity chiral social self-sorting to form a racemic mixture of D 3 symmetric heterochiral [Pd 6 (L 6R/6S ) 12 ] 12+ /[Pd 6 (L 6S/6R ) 12 ] 12+ cages.