Treatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms.

Hege ElvebakkenAndreas VenizelosAurel PerrenAnne CouvelardInger Marie B LotheGeir O HjortlandTor-Åge MyklebustJohanna SvenssonHerish GarresoriChristian KerstenEva HofsliSönke DetlefsenLene W VestermarkStian KnappskogHalfdan Sorbye

Published in: British journal of cancer (2024)

Correlations between genetic alterations and response/immediate-progression to PE were frequent in NEC but affected PFS or OS only when subdividing for cell-type. The classification of digestive NEC into large- and small-cell seems therefore molecularly and clinically relevant.

Keyphrases

high grade
genome wide
machine learning
single cell
low grade
copy number
deep learning
cell therapy
gene expression
dna methylation