Nontargeted metabolomics reveals the potential mechanism underlying the association between birthweight and metabolic disturbances.
Xiao ZhaiJieying LiuMiao YuQian ZhangMing LiNan ZhaoJuntao LiuYingna SongLiangkun MaRongrong LiZongxu QiaoGuifen ZhaoRuiping WangXinhua XiaoPublished in: BMC pregnancy and childbirth (2023)
These investigations demonstrate broad-scale metabolomic differences associated with newborn birthweight in both pregnant women and their newborns. The U-shaped metabolites associated with both the SGA and LGA groups might explain the U-shaped association between birthweight and metabolic dysregulation. The line-shaped metabolites might participate in intrauterine growth regulation. These observations might help to provide new insights into the insulin resistance and the risk of metabolic disturbance of SGA and LGA babies in adulthood and might identify potential new markers for adverse newborn outcomes in pregnant women.
Keyphrases
- pregnant women
- gestational age
- insulin resistance
- ms ms
- preterm birth
- metabolic syndrome
- adipose tissue
- pregnancy outcomes
- depressive symptoms
- type diabetes
- human health
- high fat diet
- preterm infants
- risk assessment
- skeletal muscle
- climate change
- glycemic control
- high fat diet induced
- simultaneous determination
- adverse drug