Using the CYP3A Activity Evaluation to Predict the Efficacy and Safety of Diazepam in Patients With Alcohol Withdrawal Syndrome.

Valentin Yurievich SkryabinMikhail S ZastrozhinElena A GrishinaKristina A RyzhikovaValery V ShipitsynIlya V BarnaTatiana E GalaktionovaAndrey V IvanovAlexander S SorokinEvgeny A BryunDmitry A Sychev

Published in: Journal of pharmacy practice (2021)

Possible relationship between the CYP3A activity, evaluated by the content of the urinary endogenous substrate of the given isoenzyme and its metabolite, the 6-beta-hydroxy cortisol (6-β-HC) / cortisol ratio, and the efficacy of diazepam was demonstrated. This possible relationship was also supported by the genotyping results. This should be taken into consideration when prescribing this drug to such patients in order to reduce the risk of pharmacoresistance.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
primary care
peritoneal dialysis
prognostic factors
genome wide
adverse drug
emergency department
alcohol consumption
patient reported