'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19.
Swapna MandalJoseph BarnettSimon E BrillJeremy Stuart BrownEmma K DennenySamanjit S HareMelissa HeightmanToby E HillmanJoseph JacobHannah C JarvisMarc Caeroos Isaac LipmanSindhu B NaiduArjun NairJoanna C PorterGillian S TomlinsonJohn R Hurstnull nullPublished in: Thorax (2020)
Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and 69% fatigue. 14.6% had depression. In those discharged with elevated biomarkers, 30.1% and 9.5% had persistently elevated d-dimer and C reactive protein, respectively. 38% of chest radiographs remained abnormal with 9% deteriorating. Systematic follow-up after hospitalisation with COVID-19 identifies the trajectory of physical and psychological symptom burden, recovery of blood biomarkers and imaging which could be used to inform the need for rehabilitation and/or further investigation.
Keyphrases
- coronavirus disease
- sars cov
- sleep quality
- high resolution
- end stage renal disease
- newly diagnosed
- respiratory syndrome coronavirus
- ejection fraction
- chronic kidney disease
- emergency department
- depressive symptoms
- mental health
- risk factors
- genome wide
- prognostic factors
- gene expression
- peritoneal dialysis
- dna methylation
- fluorescence imaging
- clinical evaluation