Mycophenolic acid area under the concentration-time curve is associated with therapeutic response in childhood-onset lupus nephritis.
Astrid Godron-DubrasquetJean-Baptiste WoillardStéphane DecramerMarc FilaVincent GuigonisStéphanie TellierDenis MorinMaud SordetFrank Saint-MarcouxJerome HarambatPublished in: Pediatric nephrology (Berlin, Germany) (2020)
Therapeutic drug monitoring leading to individualized dosing may improve efficacy of MMF. MPA-AUC > 45 mg h/L is associated with better response rate and may be considered as a target value in pediatric lupus nephritis.
Keyphrases