Histoplasmosis Beyond Human Immunodeficiency Virus (HIV): Clinical Characteristics and Outcomes in a Non-HIV Population.
Andrea C Tello-MercadoBernardo A Martínez-GuerraCarla M Román-MontesLisset Seoane-HernandezAndrea Rangel-CorderoRosa A Martínez-GamboaJosé Sifuentes-OsornioAlfredo Ponce-de-LeónMaria Fernanda Gonzalez-LaraMaría D Niembro-OrtegaPublished in: Open forum infectious diseases (2024)
Histoplasmosis is an endemic and invasive mycosis caused by Histoplasma capsulatum . We conducted a retrospective study comparing immunosuppressed patients without human immunodeficiency virus (HIV) with a historical cohort of people with HIV and histoplasmosis. We included 199 patients with proven or probable histoplasmosis, of which 25.1% were people without HIV. Diabetes mellitus, chronic kidney disease, hematologic neoplasms, rheumatologic diseases, and transplantations were more frequent among people without HIV ( P < .01). Forty-four percent of immunocompromised patients without HIV died within the first 6-week period following their diagnosis. A high suspicion index for histoplasmosis should be kept in immunosuppressed patients.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- hepatitis c virus
- hiv positive
- end stage renal disease
- chronic kidney disease
- hiv aids
- hiv testing
- peritoneal dialysis
- men who have sex with men
- ejection fraction
- newly diagnosed
- prognostic factors
- south africa
- intensive care unit
- clinical trial
- type diabetes
- skeletal muscle
- insulin resistance
- study protocol