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Histoplasmosis Beyond Human Immunodeficiency Virus (HIV): Clinical Characteristics and Outcomes in a Non-HIV Population.

Andrea C Tello-MercadoBernardo A Martínez-GuerraCarla M Román-MontesLisset Seoane-HernandezAndrea Rangel-CorderoRosa A Martínez-GamboaJosé Sifuentes-OsornioAlfredo Ponce-de-LeónMaria Fernanda Gonzalez-LaraMaría D Niembro-Ortega
Published in: Open forum infectious diseases (2024)
Histoplasmosis is an endemic and invasive mycosis caused by Histoplasma capsulatum . We conducted a retrospective study comparing immunosuppressed patients without human immunodeficiency virus (HIV) with a historical cohort of people with HIV and histoplasmosis. We included 199 patients with proven or probable histoplasmosis, of which 25.1% were people without HIV. Diabetes mellitus, chronic kidney disease, hematologic neoplasms, rheumatologic diseases, and transplantations were more frequent among people without HIV ( P < .01). Forty-four percent of immunocompromised patients without HIV died within the first 6-week period following their diagnosis. A high suspicion index for histoplasmosis should be kept in immunosuppressed patients.
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