MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death.

Dan JiaoHuan ZhangZiping JiangWenlin HuangZhuo LiuZhaohui WangYonggang WangHao Wu

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

MiR-34a mediates diabetes-induced TACD via inhibition of SIRT1. The novel SIRT1 activator SRT2104 attenuates diabetes-induced TACD. MiR-34a inhibition activates SIRT1 and prevents diabetes-induced TACD.

Keyphrases

type diabetes
cell death
high glucose
cardiovascular disease
diabetic rats
glycemic control
oxidative stress
cell proliferation
drug induced
endothelial cells
ischemia reperfusion injury
long noncoding rna
adipose tissue
metabolic syndrome
stress induced
cell cycle arrest
nuclear factor
germ cell