Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP.

Annette MasuchMaik PietznerMartin BahlsKathrin BuddeGabi KastenmüllerStephanie ZyllaAnna ArtatiJerzy AdamskiHenry VölzkeMarcus DörrStephan B FelixMatthias NauckNele Friedrich

Published in: Cardiovascular diabetology (2018)

Most of the metabolic changes associated with NT-proBNP implicate significant influence on the blood lipid profile besides vasodilatory and the diuretic action of BNP signaling. Our data suggest that the more favorable lipoprotein profile as associated with elevated NT-proBNP concentrations in mainly cardiac healthy individuals might relate to adiponectin signaling indicating even indirect cardio-protective effects for NT-proBNP.

Keyphrases

metabolic syndrome
insulin resistance
big data
heart failure
machine learning
artificial intelligence
acute heart failure