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Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP.

Annette MasuchMaik PietznerMartin BahlsKathrin BuddeGabi KastenmüllerStephanie ZyllaAnna ArtatiJerzy AdamskiHenry VölzkeMarcus DörrStephan B FelixMatthias NauckNele Friedrich
Published in: Cardiovascular diabetology (2018)
Most of the metabolic changes associated with NT-proBNP implicate significant influence on the blood lipid profile besides vasodilatory and the diuretic action of BNP signaling. Our data suggest that the more favorable lipoprotein profile as associated with elevated NT-proBNP concentrations in mainly cardiac healthy individuals might relate to adiponectin signaling indicating even indirect cardio-protective effects for NT-proBNP.
Keyphrases
  • metabolic syndrome
  • insulin resistance
  • big data
  • heart failure
  • machine learning
  • artificial intelligence
  • acute heart failure