Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels.
Yue RuanSubao JiangAdrian GerickePublished in: International journal of molecular sciences (2021)
Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.
Keyphrases
- age related macular degeneration
- oxidative stress
- risk factors
- end stage renal disease
- reactive oxygen species
- dna damage
- chronic kidney disease
- newly diagnosed
- ischemia reperfusion injury
- ejection fraction
- peritoneal dialysis
- induced apoptosis
- prognostic factors
- diabetic rats
- heat shock
- signaling pathway
- endoplasmic reticulum stress