miR-184 represses β-catenin and behaves as a skin tumor suppressor.
Lubov TurovskyGhazal KheshaibounGharam YassenSara NagosaIlanit BoyangoAya Amitai-LangeSwarnabh BhattacharyaNeta IlanIsrael VlodavskyDaniel AberdamRuby Shalom-FeuersteinAvitan-Hersh EmilyPublished in: Cell death & disease (2024)
miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.
Keyphrases
- cell proliferation
- long non coding rna
- long noncoding rna
- squamous cell carcinoma
- stem cells
- cell cycle
- pi k akt
- endothelial cells
- epithelial mesenchymal transition
- induced apoptosis
- mesenchymal stem cells
- cell cycle arrest
- soft tissue
- oxidative stress
- cell death
- climate change
- skeletal muscle
- signaling pathway
- lymph node metastasis
- anti inflammatory
- locally advanced