Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway.

Xinhui WuKangxian ZhaoXiaoxin FangFeng LuWeikang ZhangXiaoting SongLihua ChenJiacheng SunHaixiao Chen

Published in: Drug design, development and therapy (2021)

SSD inhibited osteoclastogenesis and LPS-induced osteolysis in mice both which served as a new potential agent for the treatment of osteoclast-related conditions.

Keyphrases

bone loss
inflammatory response
lipopolysaccharide induced
lps induced
toll like receptor
oxidative stress
combination therapy
metabolic syndrome
risk assessment
type diabetes
adipose tissue
skeletal muscle
high fat diet induced