The Role of Collagen VI α6 Chain Gene in Atopic Dermatitis.
Hye Jung JungWon Il HeoKui Young ParkMi Kyung LeeJi Young AhnMi Youn ParkSeong Jun SeoPublished in: Annals of dermatology (2022)
The reduction of epidermal COL6A6 due to the genetic mutation can cause skin barrier damage and it can contributes to the early onset of AD. COL6A6 is induced by IL-4 and IL-13, and it may play a role in fibrotic remodeling and inflammatory processes, which are major features of AD.