In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine.
Feifei ChenHui JiangJia XuShuanghu WangDeru MengPeiwu GengDapeng DaiQuan ZhouYunfang ZhouPublished in: Drug design, development and therapy (2020)
Vonoprazan significantly alters the pharmacokinetics of venlafaxine in vitro and in vivo. Further investigations should be conducted to check these effects in humans. Therapeutic drug monitoring of venlafaxine in individuals undergoing venlafaxine maintenance therapy is recommended when vonoprazan is used concomitantly.