Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents.

Jin Li 李瑾Bing LiuTobias BanaschewskiArun L W BokdeErin Burke QuinlanSylvane DesrivièresHerta FlorVincent FrouinHugh GaravanPenny GowlandAndreas HeinzBernd IttermannJean-Luc MartinotEric ArtigesFrauke NeesDimitri Papadopoulos OrfanosTomáš PausLuise PoustkaSarah HohmannJuliane H FröhnerMichael N SmolkaHenrik WalterRobert WhelanGunter Schumannnull nullTianzi Jiang

Published in: Psychological medicine (2020)

Our data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.

Keyphrases

smoking cessation
young adults
physical activity
electronic health record
big data
current status
machine learning
depressive symptoms