Minor neuropsychological deficits in patients with subjective cognitive decline.
Steffen WolfsgruberLuca KleineidamJannis GuskiAlexandra PolcherIngo FrommannSandra RoeskeEike Jakob SpruthChristiana FrankeJosef PrillerIngo KilimannStefan TeipelKatharina BuergerDaniel JanowitzChristoph LaskeMartina BuchmannOliver PetersFelix MenneManuel Fuentes CasanJens WiltfangClaudia BartelsEmrah DüzelCoraline MetzgerWenzel GlanzManuela ThelenAnnika SpottkeAlfredo RamirezBarbara KoflerKlaus FließbachAnja SchneiderMichael T HenekaFrederic BrosseronDix MeiberthFrank JessenMichael Wagnernull nullPublished in: Neurology (2020)
Within the spectrum of clinically unimpaired (i.e., before mild cognitive impairment) cognitive performance, SCD is associated with minor deficits in memory, executive function, and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.